The history of St. Pius Tenth Parish is intertwined with that of St. Benedict's Parish. The first Catholic Church consecrated in Greensboro was St. Agnes, which was dedicated in 1877. The Benedictine Fathers assumed responsibility for the St. Agnes Mission in 1888, and when a new church was built in 1899 the name of the mission was changed from St. Agnes to St. Benedict. St. Benedict's School was opened in September, 1926.

Twenty-five years later, enrollment at St. Benedict's School reached capacity and a site search was begun for a larger school. Bishop Waters and Monsignor Hugh Dolan, pastor of St. Benedict's, along with the assistance of able laymen purchased 14 acres of land at the northeast corner of North Elm Street and East Cornwallis Drive and a plant consisting of a school having eight grades and a kindergarten, a school hall and cafeteria and a chapel intended for students was built together with a Convent and Rectory.

The new school opened in March 1955 with 176 students and was named St. Pius Tenth in honor of the Pope who was canonized that year. Msgr. Dolan, after having supervised the financing and building of the plant, became the first pastor of St. Pius Tenth Church, assisted by the Daughters of Charity of Emmitsburg, Maryland.

After serving 20 years at St. Pius Tenth, Msgr. Dolan was transferred to Charlotte and Monsignor Lawrence Newman, his successor became known as a man dedicated to Catholic School education.

In 1977, Msgr. William N. Pharr succeeded Msgr. Newman. While the St. Pius Tenth Chapel was designed primarily to meet the needs of the school, the small chapel became the parish focal point for worship through two decades. Under Msgr. Pharr's leadership, the St. Pius Tenth Parish authorized a study to determine the feasibility of building a new church. On December 6, 1978, the parish presented its formal request to the Diocese.

Father George M. Kloster came to St. Pius Tenth in July of 1979. Following a year of planning and fundraising, ground was broken for the new church on March 2, 1980. On March 29, 1981, the official dedication of the new building took place.

Fr. Kloster remained pastor until June 1988 and was followed by Fr. Frank Cintula. Fr. Cintula's pastorate ended in June 1990. In July 1990 the Franciscans began serving our parish with Fr. Bob Hudak as Pastor, followed by Fr. Hugh Hines and Fr. Bob Menard. Fr. Francis Connolly arrived at St. Pius Tenth in October 1994. In the six years of his leadership, a new parish center, a parking lot, and a new school wing were built. Also, construction began on a new athletic center, which today bears his name.

Our present pastor, Msgr. Anthony Marcaccio, came to St. Pius the Tenth in July of 2000. Since his arrival, a rectory has been purchased on North Elm Street and endowments have been established for the parish and school. In 2002 we welcomed the Triad Catholic Korean Community which continues to worship here on Sunday afternoons.